ACLScor™

Pharmacogenonics cardiology

Pharmacogenomics (PGx) in Cardiology– Benefits of Personalized Prescribing


Until recently, cardiologists had little choice but to prescribe medications without knowing in advance how their patients might respond. Today, ACLScor™ makes it possible for physicians to know, before they prescribe, which medications will be most effective based on individual genetic profiles – and which ones will not.


What is included in this test bundle?

UDT

The use of urine drug testing has increased over recent years. Physicians can use UDT to assist in monitoring treatment plans in a patient-centered fashion, where the patient and physician interests are maintained.

OFT

Oral fluid testing provides confidential lab-based drug test results in an easy-to-use collection method. Donors can collect samples on-site, reducing the likelihood of tampering.

PGx – Cardio

One of the many challenges in the cardiology setting is treating patients who are already taking multiple medications. Until recently practitioners had no choice than to prescribe treatment without understanding how individual patients will respond. Pharmacogenomic testing provides valuable personalized information about the patient and the potential outcomes of treatment.


Cardiac Medicines with Significant Pharmacogenetic Information

DrugBiomarkerDrugBiomarker
CarvedilolCYP2D6PropafenoneCYP2D6
ClopidogrelCYP2C19PropranololCYP2D6
Isosorbide and hydralazineNAT1;NAT2Quinidine / DextromethorphanCYP2D6
MetoprololCYP2D6TicagrelorCYP2C19
PrasugrelCYP2C19WarfarinCYP2C9 and VKORC1

ACLScor™ Helps You Achieve Optimal Prescribing

Many important medications used to treat cardiac conditions are metabolized by CYP2D6, CYP2C9, CYP2C19, CYP3A4 or CYP3A5. Genetic variations in these cytochromes are extremely common. This genetic variability is one of the most important considerations in determining how an individual patient will respond to specific medications.

ACLScor™ tests for all clinically significant genetic variants in the enzymes responsible for metabolizing the majority of medications: CYP2D6, CYP2C9, CYP2C19, CYP3A4, CYP3A5 and VKORC1, among others. The results of this test will enable healthcare providers to individualize therapeutic treatments of cardiovascular disorders for improved patient outcomes.  Healthcare providers will be better able to assess patients’ individual needs and optimize their therapy, while minimizing risks for adverse drug reactions and interactions.

Some of the commonly-prescribed medications used to treat cardiovascular disease include:

  • Warfarin (Coumadin®)
  • Clopidogrel Bisulfate (Plavix®)
  • Beta blockers
  • Statins

Having PGx actionable results of your patient will allow you to create a truly personalized treatment plan, which will results in better patient outcomes. ACLScor™ testing is the foundation of personalized medicine and it will help us select the right drug at the right dose, for the right patient.